Computational Methods for Protein-Protein Interaction Prediction

Protein-protein interactions (PPI) occur at almost every level of cell functions. The identification of interactions among proteins provides a global picture of cellular functions and biological processes. It is also an essential step in the construction of PPI networks for human and other organisms. PPI prediction has been considered to be a promising alternative to the traditional drug design techniques. The identification of possible viral-host protein interactions can lead to a better understanding of infection mechanisms and, in turn, to the development of several medication drugs and treatment optimization. This paper investigates most of the relevant existing computational approaches carried out towards this perspective and provides a comparison of these approaches. Technical challenges, unresolved issues, and future research directions in this area